AOD 9604 10mg

Aod 9604 Research and Mechanism

Aod 9604 is a modified peptide fragment derived from amino acids 177 through 191 of human growth hormone, with an added tyrosine residue at the N-terminus for enhanced stability. It was originally developed by Professor Frank Ng at Monash University in Australia in the 1990s as an anti-obesity compound. According to ABC Science, human clinical trials funded by Metabolic Pharmaceuticals showed that aod 9604 did not produce clinically meaningful weight loss outcomes across the trial population, and the obesity program was abandoned in 2007. However, the compound remains an active research tool for studying lipolysis, cartilage regeneration, and metabolic pathways in preclinical models.

Research published in Endocrinology and summarised by Peptide Journal indicates that aod 9604 may stimulate lipolysis via beta-3 adrenergic receptor pathways and hormone-sensitive lipase activation without significantly elevating IGF-1 or inducing insulin resistance. Unlike full-length human growth hormone, aod 9604 does not appear to interact with the hGH receptor in the same way. All effects described are derived from animal models and in vitro studies. This compound is sold strictly for in vitro and laboratory research use only. It is not approved by the TGA or FDA for human consumption, therapeutic use, or diagnosis.

Aod 9604 Storage and Reconstitution

Why Is My Aod 9604 Cloudy

Cloudiness after reconstitution is a common observation with aod 9604 and does not necessarily indicate degradation or contamination. Aod 9604 has a natural tendency to form a cloudy suspension or white particulate matter when mixed with bacteriostatic water alone. This is a known physicochemical characteristic of the peptide rather than a purity issue. If you observe cloudiness, allow the vial to sit at room temperature for 15 to 20 minutes and gently swirl. Do not shake vigorously. If particulates persist, light sonication in a laboratory bath may help, but avoid overheating the solution.

Why Does Aod 9604 Gel

Gelling is another documented behaviour of aod 9604. The peptide can naturally gel over time, even when reconstituted with acetic acid. This occurs because aod 9604 has a propensity to aggregate in aqueous solution, particularly at higher concentrations or when exposed to temperature fluctuations. If your aod 9604 has gelled, gently warm the vial to room temperature and swirl slowly. Do not freeze the reconstituted gel as this may cause irreversible aggregation. For best results, reconstitute at a moderate concentration and aliquot immediately to prevent gelling in the primary vial.

Reconstitution Guide

Remove the vial from freezer storage and allow it to equilibrate to room temperature for 15 to 20 minutes. Draw 2.0 to 2.5 mL of bacteriostatic water or dilute acetic acid into a sterile syringe and inject slowly down the inner vial wall to minimise foaming. Gently swirl until fully dissolved. Allow the solution to settle before aliquoting. Label with the reconstitution date and store at 2 to 8 degrees C protected from light. Use within 14 to 21 days. Do not freeze reconstituted solution.

Aod 9604 Dosage and Research Protocols

Aod 9604 Dose for Research Protocols

For laboratory research, aod 9604 is typically supplied as a 5mg lyophilised powder. Preclinical reference protocols suggest reconstituting with 2.0 to 2.5 mL of bacteriostatic water to achieve a concentration of 2.0 to 2.5 mg per mL. Murine studies have used subcutaneous administration at approximately 500 mcg per kg per day, though human equivalent scaling has not been established. Researchers investigating aod 9604 dosing should note that the compound has a relatively short plasma half-life, which may necessitate multiple administration points in extended study designs. Gently swirl the vial until fully dissolved. Do not shake vigorously. Allow the solution to settle at room temperature before aliquoting.

Storage Protocols

Store lyophilised aod 9604 at -20 degrees C protected from light and moisture. Once reconstituted, store at 2 to 8 degrees C and use within 14 to 21 days depending on your research protocol. For extended stability, aliquot into sterile vials and freeze at -20 degrees C. Avoid repeated freeze-thaw cycles.

How Aod 9604 Compares to Other Research Compounds

Aod 9604 vs Tesamorelin

Both aod 9604 and tesamorelin are studied for fat metabolism, but they operate through entirely different mechanisms. Tesamorelin is a synthetic growth hormone-releasing hormone analog that stimulates the pituitary to release endogenous growth hormone, increasing IGF-1 and targeting deep visceral fat. It is FDA-approved for HIV-associated lipodystrophy. Aod 9604 is a modified hGH fragment that does not significantly increase IGF-1 or growth hormone levels and acts directly on adipose tissue via lipase and beta-3 adrenergic pathways. For researchers studying subcutaneous fat lipolysis without systemic hormone elevation, aod 9604 offers a more targeted tool. For protocols requiring visceral fat reduction and systemic metabolic modulation, tesamorelin may be more appropriate. Which is better tesamorelin or aod 9604 depends entirely on your research question and assay design.

Aod 9604 vs Hgh Fragment 176 191

Hgh fragment 176 191 is the native linear sequence of human growth hormone amino acids 176 through 191. Aod 9604 is a modified analog consisting of amino acids 177 through 191 with an added tyrosine residue and structural stabilisation that improves resistance to enzymatic degradation. According to research summaries, both compounds appear to avoid IGF-1 elevation and blood sugar disruption, but aod 9604 has undergone more formal pharmaceutical development including six human clinical trials, whereas hgh fragment 176 191 remains primarily a preclinical research compound. Researchers often study both to compare native versus stabilised peptide behavior in metabolic assays.

Aod 9604 vs 5 Amino 1mq

Aod 9604 is a peptide fragment that targets fat metabolism through direct lipolytic signaling in adipose tissue. 5 amino 1mq is a small molecule NNMT inhibitor that may elevate NAD+ and activate SIRT1 to influence metabolic efficiency at the enzymatic level. 5 amino 1mq is typically studied for body composition and adipocyte metabolism from a cellular energy perspective, whereas aod 9604 is studied from a peptide hormone signaling perspective. These represent different mechanistic approaches to metabolic research and may be complementary in certain assay panels.

Product Specifications

Purity and Analysis

• Purity: Greater than or equal to 98% by HPLC
• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
• Molecular Formula: C78H123N23O23S2
• Molecular Weight: 1815.1 g/mol
• Appearance: White to off-white lyophilised powder
• Source: Synthetic, manufactured via solid-phase peptide synthesis

Each batch is independently tested. Request the Certificate of Analysis (COA) for your specific batch number to verify purity, mass spec, and chromatography data.

Storage and Handling

• Lyophilised storage: -20 degrees C, protected from light and moisture
• Shelf life (unreconstituted): 24 months when stored correctly
• Handling: Use sterile technique. Avoid repeated freeze-thaw cycles

Shipping and Returns

We ship aod 9604 from our Australian facility via express domestic courier. Orders placed before 2:00 PM AEST dispatch the same business day. All peptide orders are packaged in insulated, discreet packaging with cold-chain protection where required.

• Minimum order: $200 AUD
• Free shipping: Orders over $200 AUD
• Flat rate: $15 AUD for orders under $200
• Delivery time: 1 to 5 business days Australia-wide
• Returns: Unopened vials may be returned within 30 days of delivery for store credit or replacement. We do not accept returns on reconstituted or opened products due to stability concerns. Read the full returns policy.

Frequently Asked Questions

Where to inject aod 9604
This product is strictly for in vitro and laboratory research. We do not provide injection instructions for human or animal use. Any research involving administration should be conducted by qualified professionals in accordance with institutional animal ethics or laboratory protocols.

Where to get aod 9604
Pure Peptide Factory supplies research-grade aod 9604 to Australian research institutions and laboratories. We stock 5mg lyophilised vials with HPLC verification and domestic shipping. Order aod 9604 here.

Where to buy aod-9604 oral
We do not supply oral formulations of aod 9604. This product is available as a lyophilised research vial for reconstitution only. Oral bioavailability of aod 9604 has not been established in peer-reviewed research, and oral products marketed elsewhere lack clinical validation.

Where to buy aod 9604 peptide
You can buy aod 9604 peptide directly from our Australian facility. We require a minimum order of $200 AUD and offer free shipping on orders over $200 AUD. All batches include a Certificate of Analysis.

Which is better aod 9604 or tesamorelin
Which is better aod 9604 or tesamorelin depends on your research goals. Aod 9604 is a direct lipolytic peptide that does not elevate IGF-1. Tesamorelin is a GHRH analog that stimulates endogenous growth hormone and targets visceral fat. For subcutaneous fat metabolism without systemic hormone effects, aod 9604 may be preferable. For visceral fat and broader metabolic modulation, tesamorelin may be more suitable.

Why is my aod 9604 cloudy
Cloudiness is a known characteristic of aod 9604 when reconstituted with bacteriostatic water. It does not indicate contamination. Allow the vial to sit at room temperature and gently swirl. Light sonication may help if particulates persist.

Why does aod 9604 gel
Aod 9604 naturally gels over time, even with acetic acid, due to peptide aggregation in aqueous solution. This is normal and does not mean the peptide has degraded. Gentle warming and slow swirling can restore solubility.

Is aod 9604 approved for human use?
No. Aod 9604 is strictly for research and laboratory use. It is not approved by the TGA for human consumption, therapeutic application, or clinical use.

Do you ship outside Australia?
Currently, we only ship to Australian addresses. We do not export peptides due to varying international customs regulations.

How do I verify the purity of my batch?
Every batch ships with a unique batch number. Enter this number on our COA lookup page to download the HPLC and mass spec report for your specific vial.