5 Amino1MQ

5 Amino 1mq Research and Mechanism

5 amino 1mq, also referenced as 5amino1mq or 5 amino 1 mq in research literature, is a selective small molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT becomes overexpressed in metabolically active adipose tissue and depletes cellular nicotinamide pools, reducing NAD+ availability. A study published in Nature Medicine and PMC found that NNMT inhibition with 5 amino 1mq in diet-induced obese mice significantly reduced body weight and epididymal fat pad mass without reducing food intake. By blocking NNMT, 5 amino 1mq may spare nicotinamide for NAD+ synthesis via the salvage pathway, potentially elevating intracellular NAD+ and activating SIRT1 pathways associated with mitochondrial biogenesis and metabolic regulation.

It is important to note that 5 amino 1mq is a small molecule, not a peptide, though it is frequently studied alongside peptide research compounds due to shared metabolic applications. All effects described are derived from preclinical rodent and cell-culture studies. There are no completed human clinical trials establishing efficacy or safety in humans. This compound is sold strictly for in vitro and laboratory research use only. It is not approved by the TGA or FDA for human consumption, therapeutic use, or diagnosis.

5 Amino 1mq Dosage and Reconstitution

5 Amino 1mq Dose for Research Protocols

For laboratory research, 5 amino 1mq is typically supplied as a lyophilised powder requiring reconstitution. Preclinical reference data from rodent studies used subcutaneous administration at approximately 20 mg per kg per injection, though human equivalent scaling has not been established. Researchers investigating 5 amino 1mq dosage should start with low concentrations and scale according to assay requirements. A common reconstitution protocol uses 4.0 mL of bacteriostatic water per 50 mg vial to achieve a concentration of 12.5 mg per mL, allowing precise unit measurement on a U-100 syringe.

5 Amino 1mq Benefits in Preclinical Research

Studies in diet-induced obese mice suggest that NNMT inhibition with 5 amino 1mq may support reduced adipose tissue accumulation, improved lipid profiles, and preserved lean mass during caloric restriction. Researchers have also observed potential elevations in intracellular NAD+ and SIRT1 activation, which are linked to mitochondrial biogenesis and cellular energy metabolism. These findings remain preclinical and have not been validated in human trials.

Reconstitution Guide

Remove the vial from freezer storage and allow it to equilibrate to room temperature for 15 to 20 minutes. Draw 4.0 mL of bacteriostatic water into a sterile syringe and inject slowly down the inner vial wall to minimise foaming. Gently swirl until fully dissolved. Do not shake vigorously. Label with the reconstitution date and store at 2 to 8 degrees C protected from light. Use within 2 to 4 weeks. Do not freeze reconstituted solution.

Product Specifications

Purity and Analysis

• Purity: Greater than or equal to 98% by HPLC
• Chemical Name: 5-amino-1-methylquinolinium iodide
• Molecular Formula: C10H9IN2
• Molecular Weight: 284.1 g/mol
• Appearance: Yellow to orange lyophilised powder
• Class: Small molecule NNMT inhibitor

Each batch is independently tested. Request the Certificate of Analysis (COA) for your specific batch number to verify purity, mass spec, and chromatography data.

Storage and Handling

• Lyophilised storage: -20 degrees C, protected from light and moisture
• Shelf life (unreconstituted): 24 months when stored correctly
• Handling: Use sterile technique. Avoid repeated freeze-thaw cycles

How 5 Amino 1mq Compares to Other Research Compounds

5 Amino 1mq vs MOTS-c

Both 5 amino 1mq and MOTS-c are studied for metabolic regulation, but they operate through distinct mechanisms. 5 amino 1mq inhibits NNMT to potentially elevate NAD+ and activate SIRT1, primarily affecting adipose tissue metabolism. MOTS-c is a mitochondrial-derived peptide that activates AMPK and regulates cellular energy homeostasis at the mitochondrial level. Researchers often investigate 5 amino 1mq for body composition and fat metabolism protocols, while MOTS-c is more commonly studied for exercise mimetics and glucose regulation. The two may be complementary in metabolic research stacks.

5 Amino 1mq vs BPC-157

BPC-157 is a synthetic gastric pentapeptide primarily researched for tissue regeneration, wound healing, and musculoskeletal recovery. In contrast, 5 amino 1mq is a small molecule metabolic regulator targeting NNMT in adipose tissue. While BPC-157 focuses on structural repair and anti-inflammatory pathways, 5 amino 1mq focuses on cellular energy balance and metabolic efficiency. These compounds address different research questions and are not direct substitutes.

Shipping and Returns

We ship 5 amino 1mq from our Australian facility via express domestic courier. Orders placed before 2:00 PM AEST dispatch the same business day. All orders are packaged in insulated, discreet packaging with cold-chain protection where required.

• Minimum order: $200 AUD
• Free shipping: Orders over $200 AUD
• Flat rate: $15 AUD for orders under $200
• Delivery time: 1 to 5 business days Australia-wide
• Returns: Unopened vials may be returned within 30 days of delivery for store credit or replacement. We do not accept returns on reconstituted or opened products due to stability concerns. Read the full returns policy.

Frequently Asked Questions

Is 5 amino 1mq a peptide?
No. 5 amino 1mq is a small molecule NNMT inhibitor. It is not a peptide, though it is often grouped with peptide research compounds due to shared applications in metabolic and body composition studies.

Is this compound approved for human use?
No. 5 amino 1mq is strictly for research and laboratory use. It is not approved by the TGA for human consumption, therapeutic application, or clinical use.

What is the difference between the 10mg and 50mg vials?
The 50mg vial offers a bulk research quantity ideal for extended protocols or multiple assay replicates. The 10mg vial suits smaller-scale studies and method development work.

Do you ship outside Australia?
Currently, we only ship to Australian addresses. We do not export research compounds due to varying international customs regulations.

How do I verify the purity of my batch?
Every batch ships with a unique batch number. Enter this number on our COA lookup page to download the HPLC and mass spec report for your specific vial.