AICAR 50MG

Buy Aicar Research and Mechanism

Buy aicar for laboratory research into AMP-activated protein kinase (AMPK) signalling pathways. AICAR (5-aminoimidazole-4-carboxamide ribonucleoside), also known as acadesine, is a nucleoside analog that functions as an intermediate in the purine biosynthesis pathway. According to research published in PMC, AICAR enters cells and is phosphorylated to ZMP (AICA ribotide), which mimics AMP and activates AMPK through allosteric activation and promotion of Thr172 phosphorylation by LKB1.citeweb_search:30#0 This sustained AMPK activation drives metabolic reprogramming toward catabolic pathways, including increased fatty acid oxidation, enhanced glucose uptake, and mitochondrial biogenesis through PGC-1alpha activation.

Research from SeekPeptides documents that AICAR gained prominence after the 2008 Salk Institute study demonstrated that sedentary mice treated with AICAR ran 44 percent farther on treadmill tests without training or dietary changes.citeweb_search:30#1 However, SuperPower notes that AICAR is not a peptide but a nucleoside analog, commonly grouped with peptides due to shared research channels but distinct in molecular structure and pharmacology.citeweb_search:30#3 It is critical to emphasise that AICAR is not approved by the TGA or FDA for human use. It is sold strictly for in vitro and laboratory research use only.

Aicar Benefits in Research Literature

Aicar Bodybuilding and Exercise Mimetic Research

According to SeekPeptides, AICAR activates AMPK, the master regulator of cellular energy that controls whether cells burn fat or store it, determines mitochondrial multiplication, and influences glucose uptake and inflammation.citeweb_search:30#1 Every intense exercise session activates AMPK to drive fitness adaptations; AICAR triggers the same switch without physical exertion. In insulin-resistant rats, AICAR increased fatty acid uptake 2.4-fold and glucose uptake 4.9-fold in white muscle tissue, with associated 6-fold increases in glycogen synthesis.citeweb_search:30#1 These findings position AICAR as a research tool for studying exercise mimetics, metabolic adaptation, and cellular energy reprogramming in laboratory models.

Aicar Cycle and Research Protocols

Research literature indicates that AICAR studies typically employ short-term administration protocols rather than extended cycles. According to PMC clinical trial data, human studies have used continuous intravenous infusion at 0.1 mg per kg per minute for 7 hours in cardiac surgery patients, single doses of 50 to 315 mg per kg in leukemia trials, and 10 mg per kg per hour for 3 hours in healthy volunteers.citeweb_search:30#0 Preclinical exercise mimetic studies in rodents typically used 4-week protocols. For in vitro applications, working concentrations of 0.5 to 2.0 mM are common reference points for studying AMPK activation, glucose transport, and mitochondrial biogenesis. All protocols are for laboratory research only.

Aicar Dosage and Reconstitution

Aicar 50mg Dose for Research Protocols

For laboratory research, aicar 50mg is typically supplied as a lyophilised powder. According to clinical trial references, human studies have employed a wide range of doses depending on the research context: 10 to 100 mg per kg orally or intravenously in Phase I trials, 0.1 to 0.38 mg per kg per minute continuous IV infusion in cardiac surgery studies, and 50 to 315 mg per kg single doses in oncology trials.citeweb_search:30#0 For in vitro applications, 0.5 to 2.0 mM is the standard concentration range for AMPK activation studies. The 50mg vial provides sufficient material for multiple analytical experiments or cell culture protocols.