SLU-PP-322 10 mg

Slu-pp-322 Research and Mechanism

Slu-pp-322 is a synthetic small molecule agonist of the estrogen-related receptor (ERR) family, a class of orphan nuclear receptors that regulate transcriptional networks governing mitochondrial biogenesis, oxidative phosphorylation, and cellular energy metabolism. Researchers investigating what is slu-pp-322 should understand that it belongs to the same pharmacological class as SLU-PP-332, which has been extensively characterised in peer-reviewed literature. A landmark study published in PMC demonstrated that SLU-PP-332 functions as an exercise mimetic by inducing an acute aerobic exercise genetic program, increasing whole-body fatty acid oxidation by 25 percent, and reducing fat mass gain in diet-induced obese mice without altering food intake or lean mass.

Slu-pp-322 operates through pan-ERR activation, particularly at ERR-alpha and ERR-gamma, which control genes involved in oxidative metabolism, fatty acid oxidation, and skeletal muscle energetics. A review in the Journal of Renal Endocrinology notes that ERR agonists may hold utility in studying metabolic diseases where exercise is typically prescribed, including insulin resistance and obesity models. All effects described are derived from animal studies involving structurally related compounds. Slu-pp-322 is sold strictly for in vitro and laboratory research use only. It is not approved by the TGA or FDA for human consumption, therapeutic use, or diagnosis.

Slu-pp-322 ERR Agonist Pathways

As a slu-pp-322 err agonist, this compound activates estrogen-related receptors to modulate PGC-1-alpha-related networks and mitochondrial gene programs. Unlike peptide hormones that bind cell surface receptors, slu-pp-322 enters the nucleus and alters transcriptional programming, shifting cellular fuel preference toward lipid oxidation and increasing resting energy expenditure. Research on the related compound SLU-PP-332 showed no significant alteration in glucose tolerance or pyruvate tolerance in chow-fed mice, suggesting hepatic glucose output remains unaffected while muscle glucose uptake may increase. This makes slu-pp-322 a targeted tool for studying metabolic adaptation without the systemic glucose disruption seen with some other metabolic modulators.

Slu-pp-322 Exercise Mimetic Properties

The slu-pp-322 exercise mimetic profile is one of its primary research applications. In murine studies, structurally related ERR agonists shifted the respiratory exchange ratio toward fat oxidation, increased muscle pyruvate content, decreased muscle glycogen stores, and improved fatigue resistance consistent with an endurance-trained phenotype. These changes occurred without increased locomotor activity, indicating a metabolic rather than behavioural effect. For researchers studying exercise adaptation at the transcriptional level, slu-pp-322 offers a pharmacological probe to isolate mitochondrial biogenesis signalling from physical training stimuli.

Slu-pp-322 Dosage and Reconstitution

Slu-pp-322 Dose for Research Protocols

For laboratory research, slu-pp-322 is typically supplied as a 10mg lyophilised powder requiring reconstitution. Preclinical reference data from studies on the related compound SLU-PP-332 used subcutaneous or intraperitoneal administration at approximately 50 mg per kg twice daily in murine models. Researchers investigating slu-pp-322 dose should note that human equivalent scaling has not been established and that this compound is significantly more potent by weight than typical peptide research materials. A common reconstitution protocol uses 1.0 to 2.0 mL of bacteriostatic water per 10mg vial to achieve a concentration of 5 to 10 mg per mL, allowing precise volumetric measurement for assay work. Gently swirl the vial until fully dissolved. Do not shake vigorously. Allow the solution to settle at room temperature before aliquoting.

Reconstitution Guide

Remove the vial from freezer storage and allow it to equilibrate to room temperature for 15 to 20 minutes. Draw 1.0 to 2.0 mL of bacteriostatic water into a sterile syringe and inject slowly down the inner vial wall to minimise foaming. Gently swirl until fully dissolved. Label with the reconstitution date and store at 2 to 8 degrees C protected from light. Use within 14 to 21 days. Do not freeze reconstituted solution.

How Slu-pp-322 Compares to Other Research Compounds

Slu-pp-322 vs Slu-pp-332

Slu-pp-322 and slu-pp-332 are both synthetic ERR agonists with similar mechanisms, but they may differ in potency, selectivity, and solubility profiles. Slu-pp-332 has been the primary subject of published peer-reviewed research, including the 2024 PMC study demonstrating exercise mimetic and metabolic effects in obese mouse models. Slu-pp-322 is positioned as a research analog for laboratories seeking to compare receptor binding kinetics, transcriptional activation thresholds, or formulation stability against the better-characterised slu-pp-332. Both compounds are for research use only.

Slu-pp-322 vs Mots-c

MOTS-c is a mitochondrial-derived peptide that regulates metabolism through AMPK pathway activation and cellular stress response. Slu-pp-322 is a small molecule nuclear receptor agonist that operates at the transcriptional level through ERR activation. MOTS-c is typically studied for glucose homeostasis and exercise-induced stress adaptation, while slu-pp-322 is studied for mitochondrial gene programming and fatty acid oxidation at the nuclear level. These represent complementary but mechanistically distinct approaches to metabolic research.

Slu-pp-322 vs 5 Amino 1mq

5 amino 1mq is a small molecule NNMT inhibitor that may elevate NAD+ and activate SIRT1 to influence metabolic efficiency in adipose tissue. Slu-pp-322 is an ERR agonist that regulates mitochondrial and oxidative gene programs across multiple tissues including skeletal muscle and liver. 5 amino 1mq focuses on enzymatic inhibition within fat cells, while slu-pp-322 targets nuclear transcription factors with broader systemic metabolic effects. Researchers may study both to compare enzymatic versus transcriptional metabolic modulation.

Slu-pp-322 vs Aod 9604

AOD-9604 is a modified HGH fragment studied for direct lipolytic effects in adipose tissue via beta-3 adrenergic receptor pathways. Slu-pp-322 is a nuclear receptor agonist that increases whole-body fatty acid oxidation through transcriptional upregulation of oxidative metabolism genes. AOD-9604 acts locally on fat cells, while slu-pp-322 induces systemic metabolic shifts resembling aerobic exercise adaptation. These compounds address different research questions and may be used in complementary assay panels.

Slu-pp-322 vs Hgh Fragment 176 191

Hgh fragment 176 191 is a peptide fragment targeting the lipolytic domain of human growth hormone, studied for fat metabolism without IGF-1 elevation. Slu-pp-322 is a small molecule ERR agonist with no structural relationship to growth hormone. Hgh fragment 176 191 is typically investigated for subcutaneous fat reduction, while slu-pp-322 is investigated for mitochondrial biogenesis, endurance adaptation, and whole-body fuel switching. They are not interchangeable research tools.

Product Specifications

Purity and Analysis

• Purity: Greater than or equal to 98% by HPLC
• Chemical Name: Synthetic ERR agonist (small molecule)
• Molecular Formula: C18H14N2O2 (reference standard for related analogs)
• Molecular Weight: 458.6 g/mol (reference standard for related analogs)
• Appearance: White to off-white lyophilised powder
• Source: Synthetic, manufactured via organic synthesis

Each batch is independently tested. Request the Certificate of Analysis (COA) for your specific batch number to verify purity, mass spec, and chromatography data.

Storage and Handling

• Lyophilised storage: -20 degrees C, protected from light and moisture
• Shelf life (unreconstituted): 24 months when stored correctly
• Handling: Use sterile technique. Avoid repeated freeze-thaw cycles

Shipping and Returns

We ship slu-pp-322 from our Australian facility via express domestic courier. Orders placed before 2:00 PM AEST dispatch the same business day. All orders are packaged in insulated, discreet packaging with cold-chain protection where required.

• Minimum order: $200 AUD
• Free shipping: Orders over $200 AUD
• Flat rate: $15 AUD for orders under $200
• Delivery time: 1 to 5 business days Australia-wide
• Returns: Unopened vials may be returned within 30 days of delivery for store credit or replacement. We do not accept returns on reconstituted or opened products due to stability concerns. Read the full returns policy.

Frequently Asked Questions

What is slu-pp-322
Slu-pp-322 is a synthetic small molecule agonist of estrogen-related receptors (ERRs), a class of orphan nuclear receptors that regulate mitochondrial biogenesis, oxidative metabolism, and cellular energy programs. It is studied as an exercise mimetic and metabolic research compound.

What is slu pp 322
Slu pp 322 is the same compound as slu-pp-322, written without hyphens. It is a research-grade ERR agonist for laboratory use only.

Slu-pp-322 what is it used for in research
Slu-pp-322 is used to study ERR-mediated transcriptional programs, mitochondrial biogenesis, fatty acid oxidation, and exercise mimetic metabolic adaptation in preclinical models.

Is slu-pp-322 a peptide
No. Slu-pp-322 is a small molecule, not a peptide. It is frequently grouped with peptide research compounds due to shared metabolic research applications, but it operates through nuclear receptor transcription rather than peptide signalling.

Is slu-pp-322 approved for human use
No. Slu-pp-322 is strictly for research and laboratory use. It is not approved by the TGA for human consumption, therapeutic application, or clinical use.

Do you ship outside Australia
Currently, we only ship to Australian addresses. We do not export research compounds due to varying international customs regulations.

How do I verify the purity of my batch
Every batch ships with a unique batch number. Enter this number on our COA lookup page to download the HPLC and mass spec report for your specific vial.